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Scientific Publications

Publications After 1980

List of Publications Authored By Members of the Uct Porphyria Laboratory Since 1980​

As recorded on the PubMed database

Davids LM, Corrigall AV, Meissner PN. Mitochondrial targeting of human protoporphyrinogen oxidase. Cell Biol Int. 2006 May;30(5):416-26.

Corradi HR, Corrigall AV, Boix E, Mohan CG, Sturrock ED, Meissner PN, Acharya KR. Crystal structure of protoporphyrinogen oxidase from Myxococcus xanthus and its complex with the inhibitor acifluorfen. J Biol Chem. 2006 Dec 15;281(50):38625-33.

Hift RJ, Meissner PN. An analysis of 112 acute porphyric attacks in cape town, South Africa: evidence that acute intermittent porphyria and variegate porphyria differ in susceptibility and severity. Medicine (Baltimore). 2005 Jan;84(1):48-60.

Hift RJ, Meissner D, Meissner PN. A systematic study of the clinical and biochemical expression of variegate porphyria in a large South African family. Br J Dermatol. 2004 Aug;151(2):465-71.

Hift RJ, Davidson BP, van der Hooft C, Meissner DM, Meissner PN. Plasma fluorescence scanning and fecal porphyrin analysis for the diagnosis of variegate porphyria: precise determination of sensitivity and specificity with detection of protoporphyrinogen oxidase mutations as a reference standard. Clin Chem. 2004 May;50(5):915-23. Epub 2004 Feb 19.

Hift RJ, Todd G, Meissner PN, Kirsch RE. Administration of oral activated charcoal in variegate porphyria results in a paradoxical clinical and biochemical deterioration. Br J Dermatol. 2003 Dec;149(6):1266-9.

Maneli MH, Corrigall AV, Klump HH, Davids LM, Kirsch RE, Meissner PN. Kinetic and physical characterisation of recombinant wild-type and mutant human protoporphyrinogen oxidases. Biochim Biophys Acta. 2003 Aug 21;1650(1-2):10-21.

Hift RJ, Corrigall AV, Hancock V, Kannemeyer J, Kirsch RE, Meissner PN. Porphyria cutanea tarda: the etiological importance of mutations in the HFE gene and viral infection is population-dependent. Cell Mol Biol (Noisy-le-grand). 2002 Dec;48(8):853-9.

Medlock AE, Meissner PN, Davidson BP, Corrigall AV, Dailey HA. A mouse model for South African (R59W) variegate porphyria: construction and initial characterization. Cell Mol Biol (Noisy-le-grand). 2002 Feb;48(1):71-8.

Elder GH, Hift RJ. Treatment of acute porphyria. Hosp Med. 2001 Jul;62(7):422-5. Review.

Corrigall AV, Hift RJ, Davids LM, Hancock V, Meissner D, Kirsch RE, Meissner PN. Identification of the first variegate porphyria mutation in an indigenous black South African and further evidence for heterogeneity in variegate porphyria. Mol Genet Metab. 2001 May;73(1):91-6.

James MF, Hift RJ. Porphyrias. Br J Anaesth. 2000 Jul;85(1):143-53. Review. No abstract available.

Corrigall AV, Hift RJ, Davids LM, Hancock V, Meissner D, Kirsch RE, Meissner PN. Homozygous variegate porphyria in South Africa: genotypic analysis in two cases. Mol Genet Metab. 2000 Apr;69(4):323-30.

Hift RJ. The diagnosis of porphyria. S Afr Med J. 1999 Jun;89(6):611-4. No abstract available.

Ong PM, Lanyon WG, Hift RJ, Halkett J, Cramp CE, Moore MR, Connor JM. Identification of two novel mutations in the hydroxymethylbilane synthase gene in three patients from two unrelated families with acute intermittent porphyria. Hum Hered. 1998 Jan-Feb;48(1):24-9.

Corrigall AV, Hift RJ, Hancock V, Meissner D, Davids L, Kirsch RE, Meissner PN. Identification and characterisation of a deletion (537delAT) in the protoporphyrinogen oxidase gene in a South African variegate porphyria family. Hum Mutat. 1998;12(6):403-7.

Kirsch RE, Meissner PN, Hift RJ. Variegate porphyria. Semin Liver Dis. 1998;18(1):33-41. Review.

Ong PM, Lanyon WG, Graham G, Hift RJ, Halkett J, Moore MR, Connor JM. Acute intermittent porphyria: the in vitro expression of mutant hydroxymethylbilane synthase. Mol Cell Probes. 1997 Aug;11(4):293-6.

Pretorius C, du Toit JJ, du Preez JC, Meissner PN. Diagnosis of variegate porphyria at birth by demonstration of the R59W mutation. S Afr Med J. 1997 Jun;87(6):763, 765. No abstract available.

Hift RJ, Meissner PN, Corrigall AV, Ziman MR, Petersen LA, Meissner DM, Davidson BP, Sutherland J, Dailey HA, Kirsch RE. Variegate porphyria in South Africa, 1688-1996--new developments in an old disease. S Afr Med J. 1997 Jun;87(6):722-31. Review.

Elder GH, Hift RJ, Meissner PN. The acute porphyrias. Lancet. 1997 May 31;349(9065):1613-7. Review. No abstract available.

Hift RJ, Meissner PN, Kirsch RE. The clinical diagnosis, prevention and management of the hepatic porphyrias. Trop Gastroenterol. 1997 Apr-Jun;18(2):41-4. Review. No abstract available.

Moore MR, Hift RJ. Drugs in the acute porphyrias--toxicogenetic diseases. Cell Mol Biol (Noisy-le-grand). 1997 Feb;43(1):89-94.

Warnich L, Meissner PN, Hift RJ, Louw JH, van Heerden CJ, Retief AE. Mapping of the variegate porphyria (VP) gene: contradictory evidence for linkage between VP and microsatellite markers at chromosome 14q32. Hum Genet. 1996 May;97(5):690-2.

Meissner PN, Dailey TA, Hift RJ, Ziman M, Corrigall AV, Roberts AG, Meissner DM, Kirsch RE, Dailey HA. A R59W mutation in human protoporphyrinogen oxidase results in decreased enzyme activity and is prevalent in South Africans with variegate porphyria. Nat Genet. 1996 May;13(1):95-7.

Ong PM, Lanyon WG, Hift RJ, Halkett J, Moore MR, Mgone CS, Connor JM. Detection of four mutations in six unrelated South African patients with acute intermittent porphyria. Mol Cell Probes. 1996 Feb;10(1):57-61.

Dailey TA, Dailey HA, Meissner P, Prasad AR. Cloning, sequence, and expression of mouse protoporphyrinogen oxidase. Arch Biochem Biophys. 1995 Dec 20;324(2):379-84.

Bensidhoum M, Ged C, Hombrados I, Moreau-Gaudry F, Hift RS, Meissner P, Sturrock ED, de Verneuil H. Identification of two new mutations in congenital erythropoietic porphyria. Eur J Hum Genet. 1995;3(2):102-7.

Corrigall AV, Hift RJ, Adams PA, Kirsch RE. Inhibition of mammalian protoporphyrinogen oxidase by acifluorfen. Biochem Mol Biol Int. 1994 Dec;34(6):1283-9.

Hift RJ, Meissner PN, Todd G. Hepatoerythropoietic porphyria precipitated by viral hepatitis. Gut. 1993 Nov;34(11):1632-4.

Hift RJ, Meissner PN, Todd G, Kirby P, Bilsland D, Collins P, Ferguson J, Moore MR. Homozygous variegate porphyria: an evolving clinical syndrome. Postgrad Med J. 1993 Oct;69(816):781-6. Review. Erratum in: Postgrad Med J 1994 Nov;70(829):855.

Hift RJ, Meissner PN, Kirsch RE. The effect of oral activated charcoal on the course of congenital erythropoietic porphyria. Br J Dermatol. 1993 Jul;129(1):14-7.

Harrison GG, Meissner PN, Hift RJ. Anaesthesia for the porphyric patient. Anaesthesia. 1993 May;48(5):417-21. Review. No abstract available.

Meissner P, Adams P, Kirsch R. Allosteric inhibition of human lymphoblast and purified porphobilinogen deaminase by protoporphyrinogen and coproporphyrinogen. A possible mechanism for the acute attack of variegate porphyria. J Clin Invest. 1993 Apr;91(4):1436-44.

Thunell S, Floderus Y, Henrichson A, Moore MR, Meissner P, Sinclair J. Alcoholic beverages in acute porphyria. J Stud Alcohol. 1992 May;53(3):272-6.

Meissner PN, Harrison GG, Hift RJ. Propofol as an i.v. anaesthetic induction agent in variegate porphyria. Br J Anaesth. 1991 Jan;66(1):60-5.

Hift R, Sohnius U, Meissner PN. Safety of vancomycin in acute porphyria. Br J Clin Pharmacol. 1990 Feb;29(2):273-5.

Sturrock ED, Meissner PN, Maeder DL, Kirsch RE. Uroporphyrinogen decarboxylase and protoporphyrinogen oxidase in dual porphyria. S Afr Med J. 1989 Oct 21;76(8):405-8.

Hift RJ, Meissner PN. Acute intermittent porphyria--an underdiagnosed cause of abdominal pain. S Afr Med J. 1989 Jul 15;76(2):44-5. No abstract available.

Hift RJ, Meissner PN, Straughan J. Prophylaxis and treatment of malaria in people with the acute porphyrias. S Afr Med J. 1988 Oct 1;74(7):321-2. No abstract available.

Meissner PN, Meissner DM, Sturrock ED, Davidson B, Kirsch RE. Porphyria--the UCT experience. S Afr Med J. 1987 Dec 5;72(11):755-61. Review.

Meissner PN, Day RS, Moore MR, Disler PB, Harley E. Protoporphyrinogen oxidase and porphobilinogen deaminase in variegate porphyria. Eur J Clin Invest. 1986 Jun;16(3):257-61.

Harrison GG, Moore MR, Meissner PN. Porphyrinogenicity of etomidate and ketamine as continuous infusions. Screening in the DDC-primed rat model. Br J Anaesth. 1985 Apr;57(4):420-3.

[No authors listed] Porphyria. Festschrift to Professor Lennox Eales. Clin Dermatol. 1985 Apr-Jun;3(2):1-163. No abstract available.

Moore MR, Disler PB. Chemistry and biochemistry of the porphyrins and porphyrias. Clin Dermatol. 1985 Apr-Jun;3(2):7-23. No abstract available.

Moore MR, Disler PB. Biochemical diagnosis of the porphyrias. Clin Dermatol. 1985 Apr-Jun;3(2):24-40. No abstract available.

Disler PB, Moore MR. Drug therapy in the acute porphyrias. Clin Dermatol. 1985 Apr-Jun;3(2):112-24. No abstract available.

Disler PB, Moore MR. The acute attack of porphyria. Clin Dermatol. 1985 Apr-Jun;3(2):103-11. No abstract available.

Day RS. Diagnosing porphyria using magnetic circular dichroism. S Afr Med J. 1984 May 5;65(18):713-4. No abstract available.

Day RS. Use of magnetic circular dichroism in the diagnosis of porphyria. Clin Chem. 1984 May;30(5):811-3. No abstract available.

Disler PB, Lee GK, Blekkenhorst GH, Jacobs P, Graves J. Serum ferritin levels in patients with porphyria cutanea tarda. Dermatologica. 1984;168(1):16-8.

Disler PB, Blekkenhorst GH, Eales L. The biochemical diagnosis of the porphyrias. Int J Dermatol. 1984 Jan-Feb;23(1):2-10. Review. No abstract available.

King J, Day RS, Milne FJ, Bezwoda WR, Viljoen JD, Kramer S. Delayed onset of overt porphyria cutanea tarda in a patient on long-term haemodialysis. A case report. S Afr Med J. 1983 May 7;63(19):743-6.

Day RS, Strauss PC. Severe cutaneous porphyria in a 12-year-old boy: hepatoerythropoietic or symptomatic porphyria? Arch Dermatol. 1982 Sep;118(9):663-7.

Day RS, Eales L, Meissner D. Coexistent variegate porphyria and porphyria cutanea tarda. N Engl J Med. 1982 Jul 1;307(1):36-41. No abstract available.

Disler P, Day R, Burman N, Blekkenhorst G, Eales L. Treatment of hemodialysis-related porphyria cutanea tarda with plasma exchange. Am J Med. 1982 Jun;72(6):989-93.

Disler PB, Blekkenhorst GH. Drugs and the porphyrias. S Afr Med J. 1982 May 1;61(18):645-6. No abstract available.

Disler PB, Blekkenhorst GH, Eales L, Moore MR, Straughan J. Guidelines for drug prescription in patients with the acute porphyrias. S Afr Med J. 1982 May 1;61(18):656-60. Review.

Day RS, Eales L. Acute intermittent porphyria. S Afr Med J. 1982 Feb 20;61(8):260-1. No abstract available.

Disler PB, Eales L. The acute attack of porphyria. S Afr Med J. 1982 Jan 16;61(3):82-4. Review.

Day RS, Eales L. Porphyrins in renal transplantation. Nephron. 1982;30(1):22-7.

Disler P, Day B, Blekkenhorst G, Eales L. Photosensitivity in erythropoietic protoporphyria and porphyria cutanea tarda. N Engl J Med. 1981 May 28;304(22):1363-4. No abstract available.

Blekkenhorst GH, Day RS, Eales L. Studies on erythrocyte porphobilinogen deaminase and uroporphyrinogen cosynthetase in porphyria cutanea tarda. Int J Biochem. 1981;13(8):963-6. No abstract available.

Day RS, Eales L, Disler PB. Porphyrias and the kidney. Nephron. 1981;28(6):261-7. Review. No abstract available.

Day RS, Blekkenhorst GH, Eales L. Hepatic porphyrins in variegate porphyria. N Engl J Med. 1980 Dec 4;303(23):1368-9. No abstract available.

Day RS, Disler PB, Eales L. Porphyria cutanea tarda and beta-thalassaemia minor with iron overload. Br Med J. 1980 Sep 20;281(6243):809. No abstract available.

Eales L, Disler P, Day RS. The diagnosis of pulmonary tuberculosis. S Afr Med J. 1980 Aug 23;58(8):308. No abstract available.

Blekkenhorst GH, Harrison GG, Cook ES, Eales L. Screening of certain anaesthetic agents for their ability to elicit acute porphyric phases in susceptible patients. Br J Anaesth. 1980 Aug;52(8):759-62.

Blekkenhorst GH, Cook ES, Eales L. Drug safety in porphyria. Lancet. 1980 Jun 21;1(8182):1367. No abstract available.

Eales L. Liver involvement in erythropoietic protoporphyria (EP). Int J Biochem. 1980;12(5-6):915-23. No abstract available.

Eales L, Day RS, Blekkenhorst GH. The clinical and biochemical features of variegate porphyria: an analysis of 300 cases studied at Groote Schuur Hospital, Cape Town. Int J Biochem. 1980;12(5-6):837-53. No abstract available.

Eales L, Grosser Y. Unusual porphyrins in porphyric bullous fluid. Int J Biochem. 1980;12(5-6):1059-65. No abstract available.

Blekkenhorst GH, Day RS, Eales L. The effect of bleeding and iron administration on the development of hexachlorobenzene-induced rat porphyria. Int J Biochem. 1980;12(5-6):1013-7. No abstract available.

Day RS, Blekkenhorst GH, Eales L. Drug induced acute porphyric episodes in rats. Int J Biochem. 1980;12(5-6):1007-11. No abstract available.

Day RS, Eales L. Porphyrins in chronic renal failure. Nephron. 1980;26(2):90-5.